• Angela R Garcia

    ASU Postdoctoral Research Fellow | Biological Anthropology

    I take a complex systems approach to explore interactions between genetics, gene regulation, psychosocial stress, hormones, and immune function in order to understand the physiology of disparities in health and aging within and between populations. Specifically, my research employs methods and perspectives from chronobiology, evolutionary medicine, and anthropology to study variation in risk for cardiometabolic diseases (e.g. type-2 diabetes and cardiovascular disease), and Alzheimer’s disease (AD) and other dementias. My interests are in understanding how environmental features influence susceptibilities and triggers for disease. I focus on how “upstream” factors like psychosocial (depression, social isolation, discrimination) and ecological (parasite exposure) stress influence disease risk through their influence on neuroendocrine-immune signaling.

     

    At present I am a postdoctoral research fellow in the Center for Evolution and Medicine at ASU. I investigate the effects of changing social and ecological milieu on CVD and AD risk through evaluating the biological networks through which which infection and social stress influence gene expression, as well as identifying unique and canonical genetic pathways that converge on shared risk factors.

     

  • PUBLICATIONS AND TALKS

    Peer-reviewed publications and invited talks

    Publications

     

    Full list of publications can be found at: https://scholar.google.com/citations?user=URCfj8EAAAAJ&hl=en

     

    2021

    APOE4 allele is associated with elevated blood lipids, yet lower innate immune function, in a Tropical Amerindian population with high pathogen exposure. Garcia AR, Finch CE, Gatz M, Kraft T, Cummings D, Stieglitz J, Eid Rodriguez D, Buetow K, Thomas G, Gurven M, Kaplan H, Trumble B.

    eLife. 68231.


    The indigenous South American Tsimane exhibit relatively modest decrease in brain volume with age despite high systemic inflammation. Andrei Irimia, Nikhil N Chaudhari, David J Robles ... Angela R Garcia, Paul L Hooper, Jonathan Stieglitz, Benjamin C Trumble, Michael D Gurven, Gregory S Thomas, Caleb E Finch, Hillard Kaplan.

    The Journals of Gerontology: Series A. glab138


    Do wealth and inequality associate with heath in a small-scale subsistence society? Jaeggi AV, Blackwell AD, von Rueden C, Trumble BC, Stieglitz J, Garcia AR, Kaplan H, Gurven M. Evolution, Medicine, and Public Health. 10, e59437.


    A field method for cryopreservation of whole blood for later analysis with flow cytometry. Blackwell AD, Garcia AR, Keivanfar N, Bay S.

    American Journal of Physical Anthropology. ajpa.24251.


    2020

    Multi-system physiological dysregulation and ageing in a subsistence population. TS Kraft, J Stieglitz, BC Trumble, AR Garcia, H Kaplan, M Gurven

    Philosophical Transactions of the Royal Society 375 (1811)

     

    Evidence for height and immune function tradeoffs among preadolescents in a high pathogen population. AR Garcia, AD Blackwell, BC Trumble, J Stieglitz, H Kaplan, MD Gurven

    Evolution, Medicine, and Public Health, eoaa017

     

    Does exposure to parasites modify relationships between diurnal cortisol and leukocytes among Honduran women?. AR Garcia, B Trumble, TS Kraft, S Murillo, M Marquez, M Gurven, AD Blackwell

    American Journal of Physical Anthropology, e24110

     

    Evolution of Immune Sexual Dimorphism in Response to Placental Invasiveness: A Reply to Greenbaum and Greenbaum. AR Garcia, H Natri, KH Buetow, BC Trumble, MA Wilson

    Trends in Genetics 36 (1), 5-7

     

    2019

    Endogenous Retroviruses and the Pregnancy Compensation Hypothesis: A Reply to David. H Natri, AR Garcia, KH Buetow, BC Trumble, MA Wilson

    Trends in Genetics

     

    The Pregnancy Pickle: Evolved Immune Compensation Due to Pregnancy Underlies Sex Differences in Human Diseases. Natri H, Garcia AR, Buetow K, Trumble B, Wilson MA

    Trends in Genetics, Volume 35, Issue 7, 478 - 488, DOI: 10.1016/j.tig.2019.04.008

     

     2018

    Dissertation: The Embodiment of Stress: Do cortisol-immune interactions moderate social influences on health?

    Garcia AR

    UC Santa Barbara

     

    2017

    The physiological constellation of deprivation: Immunological strategies and health outcomes. Garcia AR and Blackwell AD.

    Behavioral and Brain Sciences, 40.

     

     

    A Matter of Perception: Subjective socioeconomic status and cortisol among inhabitants of the island of Utila, Honduras. Garcia AR, Gurven M, Blackwell AD.

    American Journal of Human Biology. 1–17.

     

    Coronary atherosclerosis in indigenous South American Tsimane : a cross-sectional cohort study. Kaplan H, Thompson RC, Trumble BC, Wann LS, Allam AH, Beheim B,

    Frohlich B, Sutherland ML, Sutherland JD, Stieglitz J, Rodriguez DE, Michalik DE, Rowan CJ, Lombardi GP, Bedi R, Garcia AR, Min JK, Narula, J, Finch CE, Gurven M, Thomas, GS.

    Lancet. 15, 1–9.

    Select Invited Talks

    2021
    "Systems within systems: A multi-level approach to understanding patterns of health and disease" CEMinar series lecture, ASU.

     

    "Using a multi-level systems approach to address structural violence in COVID- 19 and other health inequities", AAAG- AAPA Joint Symposium: Thinking beyond the lab? Anthropological geneticists’ response to the COVID-19 pandemic and the summer of civil unrest

     

    "Mismatch: traits in the wrong place, or the wrong time", Evolutionary Mismatch in the Genomics Era Symposium, virtual (hosted by Princeton University)

     

    2020            

    "Evidence for height and immune function trade-offs among pre-adolescents in a high pathogen population", Club EvMed, virtual evolutionary medicine conversations

        

    "Disparities in Health: disentangling biocultural influences on variation in health between and within populations", Center for Evolution and Medicine, ASU

     

    "Eco-social dynamics in determining health-related traits in humans", ASM 300, School of Human Evolution and Social Change, ASU

     

    "Social Disparities in Health: unpacking variation in disease risk between and within populations", Emory University

     

    "Integrating multilevel data to address questions of human health and disease", Computing for Research, School of Life Sciences, ASU

     

    2019            

    "Disparities in Health: what drives variation in disease risk between and within populations?", Graduate Student Colloquium, UCSB

     

    "Disparities in Health: what drives variation in disease risk between and within populations?", Intro to Bio Anthropology, Maricopa Community College

     

    "Stress and Immune Regulation in Ecological Context: Past Exposures and Future Responses", Center for Evolution and Medicine seminar series, ASU

     

    "Social Disparities in Health: Endocrine-immune signaling mediates social influences on disease risk", Equality Health

     

    "Social Disparities in Health: Endocrine-immune signaling mediates social influences on disease risk", University of New Mexico

     

    “The embodiment of stress: do neuroendocrine-immune interactions moderate social influences on health?”, UC Los Angeles BEC Talk

     

    “Social Disparities in Health: Endocrine-immune signaling mediates social influences on disease risk”, Penn State University Early Career Seminar Program

     

    “Ecoimmunology: a role for parasites moderating neuroendocrine-immune signaling pathways”, Washington State University

     

     

     

     

  • EDUCATION

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    University of California Santa Barbara

    Ph.D. (2015-2018)

    Biological Anthropology

    Dissertation title: "Do neuroendocrine-immune interactions moderate social influences on metabolic disease risk among Honduran immigrant women?"

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    University of California Santa Barbara

    M.A. (2011-2015)

    Biological Anthropology

    Master's thesis title: "A Matter of Perception: subjective SES versus objective SES and diurnal salivary cortisol among inhabitants of the Honduran island of Utila"

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    Wayne State University

    B.A. 2002-2007

    Sociology

    Thesis: "The medicalization of normality: how medical diagnoses affect perceptions of gender and self" 

  • FIELD RESEARCH

    Research Project Design and Management

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    Utila, Islas de Bahia, Honduras

    2007 - present

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    Tsimane and Moseten populations, Bolivia

    2016- present

     

  • PRESS

    The times our research has been highlighted by others

  • CONTACT

    Center for Evolution and Medicine
    427 East Tyler Mall
    Life Sciences C Wing. rm 210
    Tempe, AZ
    85287